Obesity is a serious chronic disease
650m
people are currently living with obesity globally.
2x
The global prevalence of obesity has more than doubled since 1975.
20%+
weight loss without surgery is our ambition for patients.
$1.2tn
is the expected global cost of treating obesity-related complications by 2025.
Why do we gain weight differently?
Obesity is not a life choice
Obesity is influenced by many factors both inside and outside of the body. A person could be born with a tendency to put on weight. Just as someone is born with a particular eye colour.
There is also the physiological aspect. When a person eats, hormone signals from the stomach and gut are translated into feelings of reduced hunger and increased satiety. This controls a person's food intake.
During weight loss, the level of hormones can change in an attempt to regain the lost weight. As a result, studies show that only about one third of people successfully maintain their lost weight.
Many aspects of a person's general well-being, environment and lifestyle can also cause weight gain. Where a person lives and the culture that surrounds them can also influence the risk of developing obesity.
So, although many people with obesity believe they should be able to manage their weight on their own, it is not that easy.
Vicki Mooney lives in Spain and has obesity.
The brain’s influence on body weight
To understand obesity, we must understand what is going on in our brains. It seems our bodies are hard-wired to hang on to those extra calories, probably because for thousands of years, it was a basic survival mechanism.
Therefore, people living with obesity struggle to lose weight. Their bodies programming works to get them back to thier original starting weight. In the brain, it's as if there is a switch that tweaks a person’s energy expenditure until they have regained the lost kilos.
We are trying to pinpoint where exactly in the brain such a switch could be located and exploring whether it is something we could address with a medicine. So that one day, we might be able to help people with obesity to ‘reset’ their weight to a new, healthier starting point.
If we succeed, we could help millions of people living with obesity.
A holistic approach to treating obesity
We aim to be the leading force in the science behind obesity.
We pay great attention to the natural GLP-1 hormone. We are uncovering more and more about the role this naturally occurring hormone appears to play in achieving successful weight loss. For example, after a person has finished a meal, the GLP-1 molecules in the body affects their feelings of hunger.
For several years, our scientists have studied how synthetic GLP-1 molecules can be used to suppress appetite or increase energy expenditure. And we will continue to examine how GLP-1 can spur long-lasting weight loss.
Currently, we are researching into the following areas:
- 20% weight reduction
- Cardiovascular benefit
