Haemostasis Management

What is haemostasis?

Haemostasis is the human body's response to blood vessel injury and bleeding.  It involves a series of interactions between cells in the blood called platelets and numerous blood clotting proteins (or factors), resulting in the formation of a blood clot.

Generally, in healthy people control of bleeding is achieved very quickly and without the need for medical intervention. In major trauma or surgery, physicians often need to help patients to achieve adequate haemostasis - in order to minimise blood loss and related injury.

What is congenital haemophilia?

Haemophilia is an inherited (congenital) bleeding disorder that occurs frequently in males. It occurs when the levels of certain clotting factors (factors VIII or IX) are reduced, or are completely absent. This is because the gene that controls the production of the clotting factor does not work properly. In the case of haemophilia A, there is a problem with factor VIII and in haemophilia B it is factor IX. These clotting factors are essential in order to prevent uncontrolled bleeding.

Without these clotting factors, bleeding will continue until treatment is given because the body is not able to produce sufficient natural clotting factors to form a clot to stop it.

What are inhibitors?

The normal treatment for haemophilia is to replace the missing clotting factor. However, some people's immune systems respond to these replacement factors by developing antibodies known as inhibitors that prevent the clotting factor from working.


Reviewed: August 2019